GSK-3 inhibitor 3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK-3 inhibitor 3 是 GSK-3 的选择性、具有口服活性和脑渗透性的抑制剂，对 GSK-3α 和 GSK-3β 的 IC50s 分别为 0.35 nM 和 0.25 nM。在三重转基因小鼠阿尔茨海默病模型中，GSK-3 inhibitor 3 降低 Tau 蛋白 (tau protein) S396 磷酸化水平，IC50为 10 nM。GSK-3 inhibitor 3 可用于神经系统疾病研究。

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research.

——

——

——

Others

Other Targets

Microtubule Associated | GSK-3

——

——

2227279-84-5

410.4

C23H15FN6O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (121.83 mM; 超声助溶 )

N(C(=O)C1=NC(NC2=CC=C(C#N)C=C2)=NC=C1)C=3C(=CC=NC3)C4=CC=C(F)C=C4

——

(-20℃)

With Ice Pack

≥ 2 years